CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands		3 Months Ended
		Mar. 31, 2019	Mar. 31, 2018
Revenues [Abstract]
Contract and other revenue		$ 48,384	$ 46,426
Operating costs and expenses:
Cost of Goods and Services Sold	[1]	4,427	4,357
Cost of contract and other revenue		6,771	12,122
Research and development	[1]	40,619	40,117
Sales, general and administrative	[1]	27,645	30,198
Restructuring charges (recoveries)		331	3,245
Total operating costs and expenses		79,793	90,039
Operating income (loss)		(31,409)	(43,613)
Interest income and other income (expense), net		7,413	9,116
Interest expense		(2,271)	(4,421)
Interest and other income (expense), net		5,142	4,695
Loss before income taxes		(26,267)	(38,918)
Provision for (benefit from) income taxes		309	(3,229)
Net Income (Loss)		$ (26,576)	$ (35,689)
Net loss per share:
Earnings Per Share, Basic		$ (0.24)	$ (0.33)
Earnings Per Share, Diluted		$ (0.24)	$ (0.33)
Weighted average shares used in per share calculation:
Basic (in shares)		109,692	109,358
Diluted (in shares)		109,692	109,358
Royalty [Member]
Revenues [Abstract]
Contract and other revenue		$ 24,853	$ 21,374
Product Revenue [Member]
Revenues [Abstract]
Contract and other revenue		8,964	7,313
Contract and other Revenue [Member]
Revenues [Abstract]
Contract and other revenue		$ 14,567	$ 17,739

[1] Includes stock-based compensation:Cost of product revenue$1 $3Research and development$3,210 $3,192Sales, general and administrative$3,978 $4,319