CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands		12 Months Ended
		Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Revenue:
Royalties		$ 289,594	$ 264,614	$ 262,415
Product revenue		36,509	26,052	17,321
Contract and other revenue		66,993	45,931	16,542
Total revenue		393,096	336,597	296,278
Operating costs and expenses:
Cost of product revenue	[1]	23,783	21,329	12,377
Cost of contract and other revenue		55,364	45,761	32,967
Research and development	[1]	149,135	129,844	111,110
Sales, general and administrative	[1]	110,940	95,145	70,554
Restructuring charges		0	0	3,576
Impairment of in-process research and development intangible asset		0	18,300	0
Change in contingent consideration liability		0	(6,845)	0
Gain from sale of intellectual property		(533)	0	(3,686)
Gain from settlement		0	(579)	(2,040)
Total operating costs and expenses		338,689	302,955	224,858
Operating income (loss)		54,407	33,642	71,420
Interest income (expense), net		1,384	1,740	1,224
Loss on Extinguishment of Debt		(1,082)	0	0
Interest expense		(13,720)	(12,745)	(12,413)
Interest and other income (expense), net		(13,418)	(11,005)	(11,189)
Income before income taxes		40,989	22,637	60,231
Provision for (benefit from) income taxes		63,851	15,817	(151,157)
Net income (loss)		$ (22,862)	$ 6,820	$ 211,388
Net income (loss) per share:
Basic (in dollars per share)		$ (0.21)	$ 0.06	$ 1.84
Diluted (in dollars per share)		$ (0.21)	$ 0.06	$ 1.80
Weighted average shares used in per share calculations:
Basic (in shares)		110,198	110,162	114,814
Diluted (in shares)		110,198	113,140	117,484

[1] * Includes stock-based compensation: Cost of product revenue$78 $56 $63Research and development$12,185 $9,165 $6,762Sales, general and administrative$15,140 $11,792 $8,271