CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands		3 Months Ended		9 Months Ended
		Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016
Revenue:
Royalties		$ 72,787	$ 68,298	$ 211,733	$ 194,010
Product revenue		8,661	7,092	27,966	14,306
Contract and other revenue		17,686	14,465	51,506	30,722
Total revenue		99,134	89,855	291,205	239,038
Operating costs and expenses:
Cost of product revenue	[1]	5,152	7,031	17,882	12,581
Cost of contract and other revenue		14,456	12,393	43,274	33,139
Research and development	[1]	36,196	33,820	109,718	91,100
Sales, general and administrative	[1]	26,799	24,795	82,122	69,679
Gain from sale of intellectual property		(479)	0	(479)	0
Gain from settlement		0	0	0	(579)
Total operating costs and expenses		82,124	78,039	252,517	205,920
Operating income (loss)		17,010	11,816	38,688	33,118
Interest income and other income (expense), net		208	142	491	1,522
Interest expense		(3,287)	(3,193)	(9,754)	(9,497)
Interest and other income (expense), net		(3,079)	(3,051)	(9,263)	(7,975)
Income before income taxes		13,931	8,765	29,425	25,143
Provision for (benefit from) income taxes		6,236	4,254	16,119	14,878
Net Income (Loss)		$ 7,695	$ 4,511	$ 13,306	$ 10,265
Net income per share:
Earnings Per Share, Basic		$ 0.07	$ 0.04	$ 0.12	$ 0.09
Earnings Per Share, Diluted		$ 0.07	$ 0.04	$ 0.12	$ 0.09
Weighted average shares used in per share calculation:
Basic (in shares)		109,555	110,214	110,353	109,951
Diluted (in shares)		113,119	113,723	113,861	112,805

[1] Includes stock-based compensation