X0306 4 2021-07-27 0 0000914475 NEUROCRINE BIOSCIENCES INC NBIX 0001557146 Lloyd-Smith Malcolm 12780 EL CAMINO REAL SAN DIEGO CA 92130 0 1 0 0 Chief Regulatory Officer Common Stock 2021-07-27 4 S 0 16709 93.8019 D 15801 D The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person at least 60 days prior to the transaction date in Box 3 above. Additionally, Issuer policy restricts the Reporting Person from amending or otherwise modifying any 10b5-1 trading plan subsequent to adoption of the plan. Represents a weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $93.13 to $95.15. The Reporting Person has provided to the issuer, and will provide to any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. /s/ Darin Lippoldt, Attorney-in-Fact 2021-07-29