X0306 4 2016-01-11 0 0000914475 NEUROCRINE BIOSCIENCES INC NBIX 0001343124 OBrien Christopher Flint 12780 EL CAMINO REAL SAN DIEGO CA 92130 0 1 0 0 Chief Medical Officer Common Stock 2016-01-11 5 S 0 E 1750 44.25 D 126794 D Sale of 1,750 shares of common stock issued upon vesting of 3,500 restricted stock units on January 11, 2016 to cover payroll and withholding taxes, with the balance of the shares (1,750) maintained by the Reporting Person; the disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person at least 90 days prior to the transaction date in Box 3 above. Additionally, Issuer policy restricts the Reporting Person from amending, canceling, suspending or otherwise modifying any 10b5-1 trading plan subsequent to adoption of the plan. Represents a weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $42.71 to $46.04. The Reporting Person has provided to the issuer, and will provide to any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. /s/ Darin Lippoldt, Attorney-In-Fact 2016-01-13