X0306 4 2013-03-28 0000914475 NEUROCRINE BIOSCIENCES INC NBIX 0001126490 POPS RICHARD F ALKERMES, INC. 852 WINTER ST WALTHAM MA 02451 1 0 0 0 Common Stock 2013-03-28 4 M 0 12000 10.60 A 12000 D Common Stock 2013-03-28 4 F 0 10469 12.15 D 1531 D Stock Option 10.60 2013-03-28 4 M 0 12000 0 D 2008-06-30 2013-06-30 Common Stock 12000 0 D The share issuance reported on Table I reflects shares issued upon the exercise of options granted on June 30, 2006, which, if unexercised, would have expired on June 30, 2013. The option exercises are reported on Table II. These option exercises were pursuant to a net issuance arrangement effected under the issuer's equity incentive plan. The number of shares issued pursuant to the net issuance arrangement was calculated as follows: the option exercise price ($10.60) was subtracted from the March 28, 2013 market close price ($12.15), and this net amount ($1.55) was then multiplied by the number of options (12,000), with the resulting amount then divided by the market close price to result in a net issuance of 1,531 shares to the optionee. The 10,469 shares underlying the remaining portion of the options are not available for reissuance, and no shares are sold into the market as part of the exercise in connection with a net issuance program. Margaret E. Valeur-Jensen, By Power of Attorney 2013-04-01