X0306 4 2016-02-07 0 0000913077 AFFYMETRIX INC AFFX 0001577539 Wood Gavin C/O AFFYMETRIX, INC. 3420 CENTRAL EXPRESSWAY SANTA CLARA CA 95051 0 1 0 0 EVP, Chief Financial Officer Common Stock 2016-02-07 4 F 0 671 0 D 95351 D Common Stock 2016-02-08 4 A 0 29859 0 A 125210 D Represents the number of shares withheld by Affymetrix, Inc. to cover the tax liability resulting from the scheduled vesting of restricted stock units previously granted. On February 8, 2016, this number of perfomance-based restricted stock units was determined to be earned with respect to the performance period ending December 31, 2015. These earned restricted stock units will vest annually over three years commencing on February 19, 2016. /s/ Siang H. Chin, Attorney-in-Fact for Gavin Wood 2016-02-09