X0306 4 2014-02-25 0 0000913077 AFFYMETRIX INC AFFX 0001323221 Weber David A C/O AFFYMETRIX, INC. 3420 CENTRAL EXPRESSWAY SANTA CLARA CA 95051 0 1 0 0 EVP, Chief Commercial Officer Common Stock 2014-02-25 4 F 0 5627 7.47 D 98690 D Represents the number of shares withheld by Affymetrix, Inc. to cover the tax liability resulting from the scheduled vesting of performance restricted stock units granted on February 14, 2013 and determined to be earned on February 11, 2014 with respect to Mr. Weber's 2013 performance. /s/ Siang H. Chin, Attorney-in-Fact for David Weber 2014-02-27