X0306 4 2014-02-25 0 0000913077 AFFYMETRIX INC AFFX 0001485088 Last Andrew J. C/O AFFYMETRIX, INC. 3420 CENTRAL EXPRESSWAY SANTA CLARA CA 95051 0 1 0 0 EVP, Chief Operating Officer Common Stock 2014-02-25 4 F 0 5554 7.47 D 133636 D Represents the number of shares withheld by Affymetrix, Inc. to cover the tax liability resulting from the scheduled vesting of performance restricted stock units granted on February 14, 2013 and determined to be earned on February 11, 2014 with respect to Dr. Last's 2013 performance. /s/ Siang H. Chin, Attorney-in-Fact for Andrew J. Last 2014-02-27