CONSOLIDATED STATEMENTS OF OPERATIONS (USD $) In Thousands, except Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
REVENUE [Abstract]
Product sales	$ 241,273	$ 277,743	$ 279,186
Services	20,158	20,565	39,563
Royalties and other revenue	6,043	12,438	8,345
Total revenue	267,474	310,746	327,094
COSTS AND EXPENSES [Abstract]
Cost of product sales	97,815	117,384	126,377
Cost of services and other	13,137	15,822	23,949
Research and development	63,591	67,934	77,358
Selling, general and administrative	109,572	114,773	130,838
Restructuring charges	0	0	2,180
Goodwill impairment adjustment	0	0	(450)
Total costs and expenses	284,115	315,913	360,252
Loss from operations	(16,641)	(5,167)	(33,158)
Interest income and other, net	(6,302)	(1,487)	2,589
Interest expense	3,813	7,706	10,945
Gain from repurchase of convertible notes	0	6,297	17,447
Loss before income taxes	(26,756)	(8,063)	(24,067)
Income tax provision (benefit)	1,405	2,170	(158)
Net loss	$ (28,161)	$ (10,233)	$ (23,909)
Basic and diluted net loss per common share (in dollars per share)	$ (0.40)	$ (0.15)	$ (0.35)
Shares used in computing basic and diluted net loss per common share (in shares)	70,877	68,856	68,722