CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (USD $) In Thousands, except Share data, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2013	Sep. 30, 2012	Sep. 30, 2013	Sep. 30, 2012
Revenues:
U.S. product revenues, net	$ 243,596	$ 218,354	$ 696,347	$ 622,389
International product revenues	12,987	11,959	40,349	35,976
Service revenues	3,755	7,215	11,044	19,544
Other revenues	5,655	653	6,961	2,531
Total revenues, net	265,993	238,181	754,701	680,440
Costs and expenses:
Cost of product revenues	60,989	55,740	179,705	168,583
Research and development	123,423	70,197	352,822	188,575
Contingent consideration	2,641	1,473	7,280	6,996
Selling, general and administrative	74,884	40,420	172,974	124,455
Total costs and expenses	261,937	167,830	712,781	488,609
Operating income	4,056	70,351	41,920	191,831
Other income (expense):
Interest income	624	817	2,084	2,233
Interest expense	(8,924)	(7,629)	(23,358)	(25,538)
Other expense	(34,871)	(3,359)	(34,777)	(6,652)
Total other income (expense), net	(43,171)	(10,171)	(56,051)	(29,957)
(Loss) income before income taxes	(39,115)	60,180	(14,131)	161,874
(Benefit) provision for income taxes	(5,220)	19,859	(1,566)	45,636
Net (loss) income	(33,895)	40,321	(12,565)	116,238
Basic net (loss) income per common share (in dollars per share)	$ (0.50)	$ 0.63	$ (0.19)	$ 1.83
Diluted net (loss) income per common share (in dollars per share)	$ (0.50)	$ 0.55	$ (0.19)	$ 1.59
Shares used in calculating:
Basic net (loss) income per common share (in shares)	67,841,665	64,048,673	66,122,521	63,521,491
Diluted net (loss) income per common share (in shares)	67,841,665	82,856,912	66,122,521	81,251,074
Total comprehensive (loss) income	$ (33,351)	$ 40,570	$ (12,464)	$ 116,497