EMPLOYEE STOCK BENEFIT PLANS (Tables)

9 Months Ended

Sep. 30, 2013

EMPLOYEE STOCK BENEFIT PLANS

Schedule of stock-based compensation expense

	Three Months Ended  September 30,						Nine Months Ended  September 30,
	2013			2012			2013			2012
	(in thousands)
Stock-based compensation expense allocation:
Cost of product revenues	$	120		$	133		$	374		$	305
Research and development	2,816			2,371			8,583			6,724
Selling, general and administrative	5,029			4,248			15,147			12,215
Total stock-based compensation	7,965			6,752			24,104			19,244
Income tax effect	(2,993		)	(2,302		)	(9,058		)	(6,770		)
After-tax effect of stock-based compensation expense	$	4,972		$	4,450		$	15,046		$	12,474

Schedule of stock option activity

	Number of shares			Weighted Average Exercise Price
Outstanding as of December 31, 2012	8,025,194			$	27.31
Granted	1,252,843			$	45.32
Exercised	(1,310,085		)	$	20.92
Canceled	(112,413		)	$	36.24
Outstanding as of September 30, 2013	7,855,539			$	31.12
Vested and exercisable as of September 30, 2013	4,685,736			$	25.10
Weighted average grant-date fair value of options granted during the period	$	14.15

Schedule of RSU activity, including PRSUs

	Number of Shares		Weighted Average Grant Date Fair Value
Nonvested as of December 31, 2012	735,939		$	35.33
Granted	443,745		$	44.15
Vested	(271,724	)	$	32.35
Forfeited	(23,722	)	$	37.75
Nonvested as of September 30, 2013	884,238		$	40.61