EMPLOYEE STOCK BENEFIT PLANS (Tables)

6 Months Ended

Jun. 30, 2013

EMPLOYEE STOCK BENEFIT PLANS

Schedule of stock-based compensation expense

	Three Months Ended  June 30,						Six Months Ended  June 30,
	2013			2012			2013			2012
	(in thousands)
Stock-based compensation expense allocation:
Cost of product revenues	$	129		$	85		$	254		$	172
Research and development	2,978			2,391			5,767			4,353
Selling, general and administrative	5,303			4,249			10,118			7,967
Total stock-based compensation	8,410			6,725			16,139			12,492
Income tax effect	(2,640		)	(2,402		)	(5,093		)	(4,475		)
After-tax effect of stock-based compensation expense	$	5,770		$	4,323		$	11,046		$	8,017

Schedule of stock option activity

	Number of shares			Weighted Average Exercise Price
Outstanding as of December 31, 2012	8,025,194			$	27.31
Granted	1,089,658			$	42.86
Exercised	(898,992		)	$	19.11
Canceled	(35,976		)	$	34.14
Outstanding as of June 30, 2013	8,179,884			$	30.26
Vested and exercisable as of June 30, 2013	4,740,039			$	24.33
Weighted average grant-date fair value of options granted during the period	$	13.72

Schedule of RSU activity, including PRSUs

	Number of Shares		Weighted Average Grant Date Fair Value
Nonvested as of December 31, 2012	735,939		$	35.33
Granted	400,166		$	42.32
Vested	(265,942	)	$	32.09
Forfeited	(5,964	)	$	34.77
Nonvested as of June, 2013	864,199		$	39.57