<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0708</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0000908259</cik>
        <entityName>Oncotelic Therapeutics, Inc.</entityName>
        <issuerAddress>
            <street1>29397 AGOURA ROAD</street1>
            <street2>SUITE 107</street2>
            <city>AGOURA HILLS</city>
            <stateOrCountry>CA</stateOrCountry>
            <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
            <zipCode>91301</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>650-635-7000</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>MATEON THERAPEUTICS, INC.</previousName>
            <previousName>OXIGENE, INC.</previousName>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <previousName>MATEON THERAPEUTICS INC</previousName>
            <previousName>OXIGENE INC</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>VUONG</firstName>
                <lastName>TRIEU</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>29397 AGOURA ROAD</street1>
                <street2>SUITE 107</street2>
                <city>AGOURA HILLS</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>91301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>STEVEN</firstName>
                <lastName>KING</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>29397 AGOURA ROAD</street1>
                <street2>SUITE 107</street2>
                <city>AGOURA HILLS</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>91301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>ANTHONY</firstName>
                <lastName>MAIDA</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>29397 AGOURA ROAD</street1>
                <street2>SUITE 107</street2>
                <city>AGOURA HILLS</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>91301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>SHAH</firstName>
                <lastName>AMIT</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>29397 AGOURA ROAD</street1>
                <street2>SUITE 107</street2>
                <city>AGOURA HILLS</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>91301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>SEYMOUR</firstName>
                <lastName>FEIN</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>29397 AGOURA ROAD</street1>
                <street2>SUITE 107</street2>
                <city>AGOURA HILLS</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>91301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>SARAN</firstName>
                <lastName>SAUND</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>29397 AGOURA ROAD</street1>
                <street2>SUITE 107</street2>
                <city>AGOURA HILLS</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>91301</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>No Revenues</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2026-07-10</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>N.A.</recipientName>
                <recipientCRDNumber>None</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>None</street1>
                    <city>None</city>
                    <stateOrCountry>XX</stateOrCountry>
                    <stateOrCountryDescription>Unknown</stateOrCountryDescription>
                    <zipCode>None</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <description>CALIFORNIA</description>
                    <state>CT</state>
                    <description>CONNECTICUT</description>
                    <state>OH</state>
                    <description>OHIO</description>
                </statesOfSolicitationList>
                <foreignSolicitation>true</foreignSolicitation>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>711840</totalOfferingAmount>
            <totalAmountSold>711840</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse>RSUs, CONVERTIBLE INTO CONV. SERIES A PREF. SHARES, THEN INTO COMMON STOCK. GRANTED TO D&amp;Os, EMPOYEES AND ADVISORS FOR SERVICES TO THE COMPANY. RSUs ARE CONTINGENT UPON ACHIEVEMENT OF CERTAIN CORPORATE MILESTONES</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>true</hasNonAccreditedInvestors>
            <numberNonAccreditedInvestors>33</numberNonAccreditedInvestors>
            <totalNumberAlreadyInvested>33</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse>RSUs, CONVERTIBLE INTO CONV. SERIES A PREF. SHARES, THEN INTO COMMON STOCK. GRANTED TO D&amp;Os, EMPOYEES AND ADVISORS FOR SERVICES TO THE COMPANY. RSUs ARE CONTINGENT UPON ACHIEVEMENT OF CERTAIN CORPORATE MILESTONES</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>RSUs, CONVERTIBLE INTO CONV. SERIES A PREF. SHARES, THEN INTO COMMON STOCK. GRANTED TO D&amp;Os, EMPOYEES AND ADVISORS FOR SERVICES TO THE COMPANY. RSUs ARE CONTINGENT UPON ACHIEVEMENT OF CERTAIN CORPORATE MILESTONES</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Oncotelic Therapeutics, Inc.</issuerName>
                <signatureName>/s/ VUONG TRIEU</signatureName>
                <nameOfSigner>VUONG TRIEU</nameOfSigner>
                <signatureTitle>CEO</signatureTitle>
                <signatureDate>2026-07-22</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
