Income Taxes - Reconciliation of the Federal Statutory Rate to the Company's Effective Tax Rate (Detail)	12 Months Ended
Dec. 31, 2016	Dec. 31, 2015
Income Tax Disclosure [Abstract]
Federal statutory rate	34.00%	34.00%
State income taxes	0.42%	(0.49%)
Federal NOL adjustment		(0.43%)
State NOL expired or adjusted		(0.07%)
Permanent items	(0.97%)	(3.26%)
Stock compensation	(0.37%)	(0.11%)
Federal research credits	1.75%	1.86%
State rate change	0.00%	0.00%
Miscellaneous	0.00%	0.00%
(Increase)/ Decrease in Valuation Allowance	(34.83%)	(31.50%)
Provision for income taxes	0.00%	0.00%

Permanent differences.

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State rate change.

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Percentage of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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-Publisher FASB
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Percentage of domestic federal statutory tax rate applicable to pretax income (loss).

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to changes in the valuation allowance for deferred tax assets.

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations applicable to state and local income tax expense (benefit), net of federal tax expense (benefit).

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