144 0002075401 XXXXXXXX LIVE 0000907654 ORUKA THERAPEUTICS INC 000-22873 855 Oak Grove Avenue Suite 100 Menlo Park CA 94025 650-606-7910 LAURA SANDLER Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

18000 545580.00 48409232 01/02/2026 NASDAQ Common 01/02/2026 Exercise of Stock Options Issuer N 10000 01/02/2026 Cash Common 02/14/2024 Restricted Stock Units Issuer N 8000 02/14/2024 N/A Y The 10,000 securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 01/02/2026 09/19/2025 /s/ Laura Sandler