Agreement termination notice period.

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- Definition

Commitments and contingencies.

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- Definition

Expected license agreement milestone payments.

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Lease renewal start date.

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- Definition

License Agreement Percentage of Right to Buy Down Royalties

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License agreement percentage of royalty obligation.

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Royalty buy down due period.

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- Definition

Area of a real estate property.

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- Definition

Date which lease or group of leases is set to expire, in CCYY-MM-DD format.

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No definition available.

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Term of the lessee's leasing arrangement renewal, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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No definition available.

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- Definition

Amount of required minimum rental payments for leases having an initial or remaining non-cancelable letter-terms in excess of one year.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
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Amount of required minimum rental payments for operating leases having an initial or remaining non-cancelable lease term in excess of one year due in the next fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.

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Amount of required minimum rental payments for operating leases having an initial or remaining non-cancelable lease term in excess of one year due in the fourth fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.

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Amount of required minimum rental payments for operating leases having an initial or remaining non-cancelable lease term in excess of one year due in the third fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.

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Amount of required minimum rental payments for operating leases having an initial or remaining non-cancelable lease term in excess of one year due in the second fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.

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Rental expense for the reporting period incurred under operating leases, including minimum and any contingent rent expense, net of related sublease income.

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Commitments and Contingencies (Details Textual)		12 Months Ended
Commitments and Contingencies (Details Textual)	Mar. 02, 2016 USD ($)	Dec. 31, 2015 USD ($)	Dec. 31, 2014 USD ($)	Aug. 01, 2013 ft²
Commitments And Contingencies [Line Items]
Area of office facilities taken on lease \| ft²				5,300
Minimum lease payments in 2016		$ 62,000
Minimum lease payments		62,000
Rent expense		$ 81,000	$ 78,000
Royalty buy down due period		6 months
Minimum
Commitments And Contingencies [Line Items]
Percentage of royalty obligation		12.50%
Percentage of range of royalties that can be bought down		12.50%
Maximum
Commitments And Contingencies [Line Items]
Percentage of royalty obligation		25.00%
Percentage of range of royalties that can be bought down		17.00%
Clinical Research Agreement with Duke University
Commitments And Contingencies [Line Items]
Agreement termination notice period		90 days
Upon Food and Drug Administration Approval
Commitments And Contingencies [Line Items]
Expected milestone payments due upon approval		$ 8,000,000
Upon Regulatory Marketing Approval
Commitments And Contingencies [Line Items]
Expected milestone payments due upon approval		$ 5,000,000
CPEC
Commitments And Contingencies [Line Items]
Percentage of royalty obligation		5.00%
Subsequent Event
Commitments And Contingencies [Line Items]
Additional operating lease term	38 months
Lease renewal start date	Oct. 01, 2016
Lease expiration date	Nov. 30, 2019
Minimum lease payments in 2016	$ 7,000
Minimum lease payments in 2017	83,000
Minimum lease payments in 2018	88,000
Minimum lease payments in 2019	83,000
Minimum lease payments	$ 261,000