X0206 3 2025-07-01 0 0000907654 Oruka Therapeutics, Inc. ORKA 0002075401 Sandler Laura Lee C/O ORUKA THERAPEUTICS, INC. 855 OAK GROVE AVE., SUITE 100 MENLO PARK CA 94025 0 1 0 0 Chief Operating Officer Common Stock 213084 D Warrant (right to buy) 7.8 2034-07-14 Common Stock 99996 D Employee Stock Option (right to buy) 12.5 2035-01-21 Common Stock 137500 D This warrant represents a right to purchase 99,996 shares of the Issuer's common stock, one quarter of which will vest on April 3, 2025, with the remaining three quarters vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer on each such vesting date. The option vests as to 1/48 of the underlying shares monthly from January 1, 2025. /s/ Paul Quinlan, as attorney-in-fact for Laura Sandler 2025-07-01