Consolidated Statements of Operations and Comprehensive Loss (USD $) In Thousands, except Share data, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2013	Sep. 30, 2012	Sep. 30, 2013	Sep. 30, 2012
Revenues:
Product sales, net	$ 10,772	$ 10,814	$ 27,927	$ 27,988
Development and license fee revenues	2,919	2,287	9,140	10,632
Total revenues, net	13,691	13,101	37,067	38,620
Costs and expenses:
Cost of product sales	720	493	1,991	1,447
Research and development	8,105	6,158	23,226	22,664
Selling, general and administrative	8,507	9,117	29,804	29,872
Restructuring costs				1,440
Total costs and expenses	17,332	15,768	55,021	55,423
Loss from operations	(3,641)	(2,667)	(17,954)	(16,803)
Other income (expense):
Interest and other income	199	5	206	22
Interest and other expenses	(2,746)	(2,548)	(8,065)	(7,650)
Total other expense	(2,547)	(2,543)	(7,859)	(7,628)
Net loss	(6,188)	(5,210)	(25,813)	(24,431)
Other comprehensive income (loss):
Unrealized gain (loss) on investments	2	4	(3)	(1)
Comprehensive loss	(6,186)	(5,206)	(25,816)	(24,432)
Net loss attributable to common stockholders	$ (6,188)	$ (5,210)	$ (25,813)	$ (24,431)
Net loss per share attributable to common stockholders	$ (0.06)	$ (0.05)	$ (0.25)	$ (0.25)
Shares used in computing basic and diluted net loss per share of common stock	109,731,276	99,069,928	104,821,199	98,896,984