Consolidated Statements of Operations and Comprehensive Loss (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011
Revenues:
Product sales, net	$ 10,814	$ 6,597	$ 27,988	$ 15,888
Development and license fee revenues	2,287	3,535	10,632	24,333
Total revenues, net	13,101	10,132	38,620	40,221
Costs and expenses:
Cost of product sales	493	260	1,447	781
Research and development expenses	6,158	8,659	22,664	26,238
Selling, general and administrative expenses	9,117	8,790	29,872	27,120
Restructuring costs			1,440
Total costs and expenses	15,768	17,709	55,423	54,139
Income (loss) from operations	(2,667)	(7,577)	(16,803)	(13,918)
Other income (expense):
Interest income	5	382	22	544
Interest and other expenses	(2,548)	(2,528)	(7,650)	(7,690)
Total other expense	(2,543)	(2,146)	(7,628)	(7,146)
Net loss	(5,210)	(9,723)	(24,431)	(21,064)
Other comprehensive income (loss):
Unrealized gain (loss) on investments	4	(27)	(1)	(18)
Comprehensive loss	$ (5,206)	$ (9,750)	$ (24,432)	$ (21,082)
Basic and diluted net loss per share	$ (0.05)	$ (0.10)	$ (0.25)	$ (0.21)
Shares used in computing basic and diluted net loss per share	99,069,928	98,748,086	98,896,984	98,720,137