Capital Leases of Lessee, Annual Interest Rate

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- Definition

Class of Warrant or Right, Expiration Date

+ References

No definition available.

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Period Type:	instant

- Details

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- Definition

Debt Instrument, Maturity, Month and Year

+ References

No definition available.

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- Definition

Line Of Credit Facility Financing Term

+ References

No definition available.

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- Definition

Percentage of Required Payment for Partial Repayment of Debt

+ References

No definition available.

+ Details

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- Definition

The exercise price of each class of warrants or rights outstanding.

+ References

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-Publisher FASB

-Name Accounting Standards Codification

-Topic 235

-SubTopic 10

-Section S99

-Paragraph 1

-Subparagraph (SX 210.4-08.(i)(4))

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-Publisher SEC

-Name Regulation S-X (SX)

-Number 210

-Section 08

-Paragraph i

-Subparagraph 4

-Article 4

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- Definition

Aggregate amount of each class of warrants or rights outstanding.

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-Publisher FASB

-Name Statement of Financial Accounting Standard (FAS)

-Number 129

-Paragraph 4

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-Publisher FASB

-Name Accounting Standards Codification

-Topic 235

-SubTopic 10

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-Paragraph 1

-Subparagraph (SX 210.4-08.(i))

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-Publisher SEC

-Name Regulation S-X (SX)

-Number 210

-Section 08

-Paragraph i

-Article 4

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- Definition

Including current and noncurrent portions, aggregate carrying amount of long-term borrowings as of the balance sheet date before deducting unamortized discount or premiums (if any). May include notes payable, bonds payable, commercial loans, mortgage loans, convertible debt, subordinated debt and other types of debt, which had initial maturities beyond one year or beyond the normal operating cycle, if longer.

+ References

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-Publisher SEC

-Name Regulation S-X (SX)

-Number 210

-Section 03

-Paragraph 16

-Article 9

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-Publisher FASB

-Name FASB Staff Position (FSP)

-Number APB14-1

-Paragraph 31

-Subparagraph b

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-Publisher SEC

-Name Regulation S-X (SX)

-Number 210

-Section 02

-Paragraph 20

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-Publisher SEC

-Name Regulation S-X (SX)

-Number 210

-Section 02

-Paragraph 22

-Article 5

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- Definition

The stated principal amount of the debt instrument at time of issuance, which may vary from the carrying amount because of unamortized premium or discount.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 835

-SubTopic 30

-Section 45

-Paragraph 2

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-Section 55

-Paragraph 8

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-Publisher AICPA

-Name Accounting Principles Board Opinion (APB)

-Number 21

-Paragraph 16, 20

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- Definition

Net increase or decrease in the carrying amount of the debt instrument for the period for reasons other than accrued but unpaid interest, additional borrowings, forgiveness and repayments.

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-Publisher FASB

-Name Accounting Standards Codification

-Topic 235

-SubTopic 10

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-Paragraph 1

-Subparagraph (SX 210.4-08.(f))

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-Publisher SEC

-Name Regulation S-X (SX)

-Number 210

-Section 08

-Paragraph f

-Article 4

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- Definition

The effective interest rate at the end of the reporting period.

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-Publisher FASB

-Name Accounting Standards Codification

-Topic 835

-SubTopic 30

-Section 45

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-Publisher SEC

-Name Regulation S-X (SX)

-Number 210

-Section 02

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-Paragraph 1

-Subparagraph (SX 210.5-02.22(a)(1))

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- Definition

Interest rate stated in the contractual debt agreement.

+ References

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- Definition

Date when the debt instrument is scheduled to be fully repaid, in CCYY-MM-DD format.

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-Publisher SEC

-Name Regulation S-X (SX)

-Number 210

-Section 02

-Paragraph 22

-Article 5

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-Publisher FASB

-Name Accounting Standards Codification

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-Name Statement of Financial Accounting Standard (FAS)

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- Definition

Amount of dividends expected to be paid to holders of the underlying shares or contracted instruments over the term of the instruments life.

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-Publisher FASB

-Name Accounting Standards Codification

-Topic 820

-SubTopic 10

-Section 50

-Paragraph 2

-Subparagraph (e)

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- Definition

Period the instrument, asset or liability is expected to be outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

+ References

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- Definition

Measure of dispersion, in percentage terms (for instance, the standard deviation or variance), for a given stock price.

+ References

+ Details

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- Definition

Risk-free interest rate assumption used in valuing an instrument.

+ References

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- Definition

The carrying value as of the balance sheet date of the current and noncurrent portions of long-term obligations drawn from a line of credit, which is a bank's commitment to make loans up to a specific amount. Examples of items that might be included in the application of this element may consist of letters of credit, standby letters of credit, and revolving credit arrangements, under which borrowings can be made up to a maximum amount as of any point in time conditional on satisfaction of specified terms before, as of and after the date of drawdowns on the line. Includes short-term obligations that would normally be classified as current liabilities but for which (a) postbalance sheet date issuance of a long term obligation to refinance the short term obligation on a long term basis, or (b) the enterprise has entered into a financing agreement that clearly permits the enterprise to refinance the short-term obligation on a long term basis and the following conditions are met (1) the agreement does not expire within 1 year and is not cancelable by the lender except for violation of an objectively determinable provision, (2) no violation exists at the BS date, and (3) the lender has entered into the financing agreement is expected to be financially capable of honoring the agreement.

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-Publisher FASB

-Name Accounting Standards Codification

-Topic 944

-SubTopic 210

-Section S99

-Paragraph 1

-Subparagraph (SX 210.7-03.16)

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-Publisher FASB

-Name Accounting Standards Codification

-Topic 942

-SubTopic 210

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-Publisher SEC

-Name Regulation S-X (SX)

-Number 210

-Section 02

-Paragraph 19, 20, 22

-Article 5

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- Definition

Amount borrowed under the credit facility as of the balance sheet date.

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-Publisher SEC

-Name Regulation S-X (SX)

-Number 210

-Section 02

-Paragraph 19, 22

-Article 5

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- Definition

Maximum borrowing capacity under the credit facility without consideration of any current restrictions on the amount that could be borrowed or the amounts currently outstanding under the facility.

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-Publisher FASB

-Name Statement of Financial Accounting Standard (FAS)

-Number 129

-Paragraph 2, 4

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-Publisher FASB

-Name Accounting Standards Codification

-Topic 210

-SubTopic 10

-Section S99

-Paragraph 1

-Subparagraph (SX 210.5-02.19(b),22(b))

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-Publisher SEC

-Name Regulation S-X (SX)

-Number 210

-Section 02

-Paragraph 19, 22

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- Definition

This element represents the portion of the balance sheet assertion valued at fair value by the entity whether such amount is presented as a separate caption or as a parenthetical disclosure. Additionally, this element may be used in connection with the fair value disclosures required in the footnote disclosures to the financial statements. The element may be used in both the balance sheet and disclosure in the same submission. This item represents notes payable as of the balance sheet date.

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-Publisher SEC

-Name Regulation S-X (SX)

-Number 210

-Section 02

-Paragraph 19, 20, 22

-Article 5

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-Publisher FASB

-Name Statement of Financial Accounting Standard (FAS)

-Number 129

-Paragraph 2, 4

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-Publisher FASB

-Name Accounting Standards Codification

-Topic 210

-SubTopic 10

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-Paragraph 1

-Subparagraph (SX 210.5-02.19,20,22)

-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

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- Definition

Cash received from licensees for license fees during the current period.

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-Publisher FASB

-Name Accounting Standards Codification

-Topic 230

-SubTopic 10

-Section 45

-Paragraph 25

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-Publisher FASB

-Name Statement of Financial Accounting Standard (FAS)

-Number 95

-Paragraph 27

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- Definition

Cash received from principal payments made on loans related to operating activities.

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-Publisher FASB

-Name Statement of Financial Accounting Standard (FAS)

-Number 95

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-Publisher FASB

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-Subparagraph (c)

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- Definition

Carrying value as of the balance sheet date, including the current and noncurrent portions, of collateralized debt obligations (with maturities initially due after one year or beyond the operating cycle, if longer). Such obligations include mortgage loans, chattel loans, and any other borrowings secured by assets of the borrower.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher SEC

-Name Regulation S-X (SX)

-Number 210

-Section 02

-Paragraph 19, 20, 22

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-Publisher FASB

-Name Accounting Standards Codification

-Topic 944

-SubTopic 210

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-Name Accounting Standards Codification

-Topic 942

-SubTopic 210

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-Publisher SEC

-Name Regulation S-X (SX)

-Number 210

-Section 03

-Paragraph 16

-Article 9

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- Definition

Value of outstanding derivative securities that permit the holder the right to purchase securities (usually equity) from the issuer at a specified price.

+ References

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-Publisher FASB

-Name Emerging Issues Task Force (EITF)

-Number 98-5

-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

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-Publisher FASB

-Name Accounting Standards Codification

-Topic 235

-SubTopic 10

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-Name Regulation S-X (SX)

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-Name Emerging Issues Task Force (EITF)

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Note Payable - Additional Information (Detail) (USD $)	9 Months Ended	12 Months Ended		9 Months Ended			9 Months Ended						9 Months Ended	12 Months Ended		24 Months Ended				9 Months Ended					1 Months Ended
Note Payable - Additional Information (Detail) (USD $)	Sep. 30, 2012	Dec. 31, 2011	Sep. 30, 2011	Sep. 30, 2012 Warrant Tranche A loan and Tranche B Loans (Original Loan)	Sep. 30, 2012 Healthcare Royalty Partners	Dec. 31, 2011 Healthcare Royalty Partners	Sep. 30, 2012 Healthcare Royalty Partners Legal Fee	Sep. 30, 2012 Healthcare Royalty Partners Tranche B Loan Loan One	Sep. 30, 2012 Healthcare Royalty Partners Tranche B Loan Loan Two	Sep. 30, 2012 Healthcare Royalty Partners Tranche A loan and Tranche B Loans (Original Loan)	Sep. 30, 2012 Healthcare Royalty Partners Tranche A loan and Tranche B Loans (Original Loan) Phase 3 Trials	Sep. 30, 2012 Healthcare Royalty Partners Tranche A loan and Tranche B Loans (Original Loan) Group Two	Sep. 30, 2012 Healthcare Royalty Partners 2011 Additional Financing and Original Loan Modification Tranche A Loan Legal Fee	Dec. 31, 2011 Healthcare Royalty Partners 2011 Additional Financing and Original Loan Modification Second Affiliated Tranche A Loan	Sep. 30, 2012 Healthcare Royalty Partners 2011 Additional Financing and Original Loan Modification Second Affiliated Tranche A Loan	Dec. 31, 2009 Healthcare Royalty Partners 2011 Additional Financing and Original Loan Modification Second Affiliated Tranche B Loan	Sep. 30, 2012 Healthcare Royalty Partners 2011 Additional Financing and Original Loan Modification Second Affiliated Tranche B Loan	Jul. 31, 2012 Healthcare Royalty Partners 2011 Additional Financing and Original Loan Modification Second Affiliated Tranche B Loan	Dec. 31, 2011 Healthcare Royalty Partners 2011 Additional Financing and Original Loan Modification Second Affiliated Tranche B Loan	Sep. 30, 2012 Healthcare Royalty Partners Minimum Tranche A loan and Tranche B Loans (Original Loan) Group Two	Aug. 31, 2012 Healthcare Royalty Partners LFRP	Aug. 31, 2012 Healthcare Royalty Partners LFRP Tranche A Loan	Aug. 31, 2012 Healthcare Royalty Partners LFRP Tranche B Loan	Aug. 31, 2012 Healthcare Royalty Partners LFRP Tranche A loan and Tranche B Loans (Original Loan)	Jun. 30, 2012 Silicon Valley Equipment lease	Sep. 30, 2012 Silicon Valley Equipment lease	Jun. 30, 2012 Silicon Valley Equipment lease Negotiable Order of Withdrawal Accounts
Debt Disclosure [Line Items]
Secured Loan																					$ 80,500,000	$ 21,700,000	$ 58,800,000
Debt maturity date																								2018-08
Interest rate														13.00%			17.40%		102.00%					12.00%
Debt instrument maturity date										Sep. 30, 2016
Percentage of required payment for partial repayment of debt										90.00%	75.00%	25.00%
Annual net LFRP receipts amount used as a basis for repayment of loan											15,000,000									15,000,000
Proceed from unsecured loan														20,000,000		65,000,000
Effective interest rate															12.50%
Decrease in note payable	149,000	246,000		1,300,000			580,000						193,000
Principal amount of Loan																		57,600,000
Issuance of warrants to purchase common stock	11,379,953		11,682,969					250,000	250,000
Warrant exercise price per share								5.50	2.87
Warrant right expiration date								2016-08	2016-08
Estimated fair value of warrant at issuance date								853,000	477,000
Volatility factor								83.64%	85.98%
Risk-free interest rate								4.07%	2.77%
Expected term								8 years	7 years 4 months
Expected dividend yield								$ 0	$ 0
Loan principal balance					80,500,000	76,700,000
Fair value of note payable	80,500,000
Line of credit, maximum borrowing capacity																									3,000,000
Interest on lease																									6.00%
Line of credit																											1,400,000
Line of credit term																									3 years
Line of credit, outstanding balance																										$ 1,400,000