Fixed Assets (Detail) (USD $) In Thousands, unless otherwise specified	Sep. 30, 2012	Dec. 31, 2011
Fixed Assets [Line Items]
Property, plant and equipment, gross	$ 18,430	$ 25,448
Less: accumulated depreciation and amortization	(13,142)	(20,567)
Property, plant and equipment, Net	5,288	4,881
Laboratory Equipment
Fixed Assets [Line Items]
Property, plant and equipment, gross	7,629	9,103
Furniture and Office Equipment
Fixed Assets [Line Items]
Property, plant and equipment, gross	1,588	1,095
Software and Computers
Fixed Assets [Line Items]
Property, plant and equipment, gross	4,711	4,445
Leasehold Improvements
Fixed Assets [Line Items]
Property, plant and equipment, gross	4,502	6,845
Construction in Progress
Fixed Assets [Line Items]
Property, plant and equipment, gross		$ 3,960

The cumulative amount of depreciation, depletion and amortization (related to property, plant and equipment, but not including land) that has been recognized in the income statement.

+ References+ Details

Gross amount of long-lived physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, furniture and fixtures, and computer equipment.

+ References+ Details

- Definition

Amount, net of accumulated depreciation, depletion and amortization, of long-lived physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, furniture and fixtures, and computer equipment.

+ References+ Details