Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016
Revenue:
Product sales	$ 4,448	$ 14,698	$ 24,897	$ 41,664
Royalty revenue	9,302	5,573	23,953	13,150
Non-cash royalty revenue related to sale of future royalties	8,066	7,692	21,367	22,341
License, collaboration and other revenue	131,112	8,373	142,028	50,829
Total revenue	152,928	36,336	212,245	127,984
Operating costs and expenses:
Cost of goods sold	5,674	7,033	20,794	23,611
Research and development	65,714	51,951	187,032	153,569
General and administrative	12,055	10,253	40,027	31,515
Total operating costs and expenses	83,443	69,237	247,853	208,695
Income (loss) from operations	69,485	(32,901)	(35,608)	(80,711)
Non-operating income (expense):
Interest expense	(5,540)	(5,614)	(16,452)	(16,918)
Non-cash interest expense on liability related to sale of future royalties	(4,471)	(4,902)	(13,535)	(14,929)
Interest income and other income (expense), net	1,599	332	3,163	1,666
Total non-operating expense, net	(8,412)	(10,184)	(26,824)	(30,181)
Income (loss) before provision for income taxes	61,073	(43,085)	(62,432)	(110,892)
Provision for income taxes	202	139	434	433
Net income (loss)	$ 60,871	$ (43,224)	$ (62,866)	$ (111,325)
Net income (loss) per share:
Basic	$ 0.39	$ (0.32)	$ (0.41)	$ (0.82)
Diluted	$ 0.37	$ (0.32)	$ (0.41)	$ (0.82)
Weighted average shares outstanding used in computing net income (loss) per share:
Basic	156,411	137,094	155,153	136,415
Diluted	162,641	137,094	155,153	136,415