Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Revenue:
Product sales	$ 15,693	$ 12,867	$ 20,449	$ 26,966
Royalty revenue	7,434	3,516	14,651	7,576
Non-cash royalty revenue related to sale of future royalties	6,638	8,115	13,301	14,650
License, collaboration and other revenue	4,824	8,270	10,916	42,457
Total revenue	34,589	32,768	59,317	91,649
Operating costs and expenses:
Cost of goods sold	8,989	7,708	15,120	16,578
Research and development	60,260	52,350	121,318	101,618
General and administrative	15,996	11,035	27,972	21,262
Total operating costs and expenses	85,245	71,093	164,410	139,458
Loss from operations	(50,656)	(38,325)	(105,093)	(47,809)
Non-operating income (expense):
Interest expense	(5,510)	(5,627)	(10,912)	(11,304)
Non-cash interest expense on liability related to sale of future royalties	(4,512)	(4,982)	(9,064)	(10,027)
Interest income and other income (expense), net	906	458	1,564	1,333
Total non-operating expense, net	(9,116)	(10,151)	(18,412)	(19,998)
Loss before provision for income taxes	(59,772)	(48,476)	(123,505)	(67,807)
Provision for income taxes	99	127	232	294
Net loss	$ (59,871)	$ (48,603)	$ (123,737)	$ (68,101)
Basic and diluted net loss per share	$ (0.39)	$ (0.36)	$ (0.80)	$ (0.50)
Weighted average shares outstanding used in computing basic and diluted net loss per share	155,352	136,350	154,514	136,072