Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
Revenue:
Product sales	$ 4,756	$ 14,099
Royalty revenue	7,217	4,061
Non-cash royalty revenue related to sale of future royalties	6,663	6,535
License, collaboration and other revenue	6,092	34,187
Total revenue	24,728	58,882
Operating costs and expenses:
Cost of goods sold	6,131	8,870
Research and development	61,058	49,268
General and administrative	11,976	10,228
Total operating costs and expenses	79,165	68,366
Loss from operations	(54,437)	(9,484)
Non-operating income (expense):
Interest expense	(5,402)	(5,677)
Non-cash interest expense on liability related to sale of future royalties	(4,552)	(5,045)
Interest income and other income (expense), net	658	875
Total non-operating expense, net	(9,296)	(9,847)
Loss before provision for income taxes	(63,733)	(19,331)
Provision for income taxes	133	167
Net loss	$ (63,866)	$ (19,498)
Basic and diluted net loss per share	$ (0.42)	$ (0.14)
Weighted average shares outstanding used in computing basic and diluted net loss per share	153,666	135,793