Property, Plant and Equipment - Property, Plant and Equipment (Detail) - USD ($) $ in Thousands	Dec. 31, 2016	Dec. 31, 2015
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	$ 173,388	$ 165,592
Less: accumulated depreciation	(111,243)	(102,712)
Depreciable property, plant and equipment, net	62,145	62,880
Construction-in-progress	3,456	8,456
Property plant and equipment, net	65,601	71,336
Building and Leasehold Improvements [Member]
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	75,137	77,665
Manufacturing Equipment [Member]
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	44,237	35,631
Laboratory Equipment [Member]
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	27,424	27,309
Furniture, Fixtures and Other Equipment [Member]
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	$ 26,590	$ 24,987