Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Revenue:
Product sales	$ 55,354	$ 40,155	$ 25,152
Royalty revenue	19,542	2,967	329
Non-cash royalty revenue related to sale of future royalties	30,158	22,058	21,937
License, collaboration and other revenue	60,382	165,604	153,289
Total revenue	165,436	230,784	200,707
Operating costs and expenses:
Cost of goods sold	30,215	34,102	28,533
Research and development	203,801	182,787	147,734
General and administrative	44,275	43,266	40,925
Total operating costs and expenses	278,291	260,155	217,192
Loss from operations	(112,855)	(29,371)	(16,485)
Non-operating income (expense):
Interest expense	(22,468)	(18,282)	(17,869)
Non-cash interest expense on liability related to sale of future royalties	(19,712)	(20,619)	(20,888)
Loss on extinguishment of debt	0	(14,079)	0
Interest income and other income (expense), net	2,387	1,680	814
Total non-operating expense, net	(39,793)	(51,300)	(37,943)
Loss before provision (benefit) for income taxes	(152,648)	(80,671)	(54,428)
Provision (benefit) for income taxes	876	506	(512)
Net loss	$ (153,524)	$ (81,177)	$ (53,916)
Basic and diluted net loss per share	$ (1.10)	$ (0.61)	$ (0.42)
Weighted average shares outstanding used in computing basic and diluted net loss per share	139,596	132,458	126,873