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Number of customers accounted for major accounts receivable.

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Number of reporting units to evaluate goodwill for impairment

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Organization and summary of significant accounting policies.

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Percentage of accounts receivable customers one.

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Percentage of accounts receivable customers three.

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Percentage of accounts receivable customers two.

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Percentage of amount realized upon ultimate settlement.

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Reclassification of capitalized issuance costs.

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Securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) or earnings per unit (EPU) in the future that were not included in the computation of diluted EPS or EPU because to do so would increase EPS or EPU amounts or decrease loss per share or unit amounts for the period presented.

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Amount equal to the present value (the principal) at the beginning of the lease term of minimum lease payments during the lease term (excluding that portion of the payments representing executory costs such as insurance, maintenance, and taxes to be paid by the lessor, together with any profit thereon) net of payments or other amounts applied to the principal through the balance sheet date.

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Sum of the carrying values as of the balance sheet date of all debt, including all short-term borrowings, long-term debt, and capital lease obligations.

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Useful life of long lived, physical assets used in the normal conduct of business and not intended for resale, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. Examples include, but not limited to, land, buildings, machinery and equipment, office equipment, furniture and fixtures, and computer equipment.

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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) $ in Thousands, shares in Millions		12 Months Ended
	Jan. 01, 2016 USD ($)	Dec. 31, 2016 USD ($) Customer Reporting_Unit shares	Dec. 31, 2015 USD ($) Customer shares	Dec. 31, 2014 shares
Organization And Summary Of Significant Accounting Policies [Line Items]
Cash and investments in marketable securities		$ 389,102	$ 308,944
Senior secured notes		250,000
Debt and capital lease obligation		255,100
Capital lease obligations		5,100
Capital lease obligations, current portion		$ 2,908	$ 4,756
Number of customers accounted for major accounts receivable \| Customer		3	3
Percentage of accounts receivable customers one		39.00%	50.00%
Percentage of accounts receivable customers two		32.00%	35.00%
Percentage of accounts receivable customers three		13.00%	10.00%
Number of reporting unit evaluated for goodwill \| Reporting_Unit		1
Minimum percentage of amount realized upon ultimate settlement		50.00%
Senior Secured Notes [Member]
Organization And Summary Of Significant Accounting Policies [Line Items]
Reclassification of capitalized issuance costs	$ 400
Liability Related To Future Royalties Liability Balances [Member]
Organization And Summary Of Significant Accounting Policies [Line Items]
Reclassification of capitalized issuance costs	$ 3,000
Stock Options and Restricted Stock Units [Member]
Organization And Summary Of Significant Accounting Policies [Line Items]
Weighted average diluted securities excluded from diluted net loss per share \| shares		19.9	21.1	21.9
Buildings [Member]
Organization And Summary Of Significant Accounting Policies [Line Items]
Property and equipment estimated useful lives		20 years
Manufacturing Laboratory and Other Equipment [Member] \| Minimum [Member]
Organization And Summary Of Significant Accounting Policies [Line Items]
Property and equipment estimated useful lives		3 years
Manufacturing Laboratory and Other Equipment [Member] \| Maximum [Member]
Organization And Summary Of Significant Accounting Policies [Line Items]
Property and equipment estimated useful lives		10 years