Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Revenue:
Product sales	$ 14,698	$ 7,240	$ 41,664	$ 26,182
Royalty revenue	5,573	187	13,150	1,057
Non-cash royalty revenue related to sale of future royalties	7,692	6,050	22,341	14,752
License, collaboration and other revenue	8,373	46,475	50,829	149,423
Total revenue	36,336	59,952	127,984	191,414
Operating costs and expenses:
Cost of goods sold	7,033	6,760	23,611	25,738
Research and development	51,951	43,229	153,569	135,652
General and administrative	10,253	9,544	31,515	30,031
Total operating costs and expenses	69,237	59,533	208,695	191,421
Income (loss) from operations	(32,901)	419	(80,711)	(7)
Non-operating income (expense):
Interest expense	(5,614)	(4,202)	(16,918)	(12,491)
Non-cash interest expense on liability related to sale of future royalties	(4,902)	(5,226)	(14,929)	(15,428)
Interest income and other income (expense), net	332	898	1,666	1,355
Total non-operating expense, net	(10,184)	(8,530)	(30,181)	(26,564)
Loss before provision for income taxes	(43,085)	(8,111)	(110,892)	(26,571)
Provision for income taxes	139	92	433	469
Net loss	$ (43,224)	$ (8,203)	$ (111,325)	$ (27,040)
Basic and diluted net loss per share	$ (0.32)	$ (0.06)	$ (0.82)	$ (0.21)
Weighted average shares outstanding used in computing net loss per share	137,094	132,631	136,415	131,882