Condensed Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands	Sep. 30, 2016	Dec. 31, 2015
Current assets:
Cash and cash equivalents	$ 63,295	$ 55,570
Short-term investments	190,216	253,374
Accounts receivable, net	14,249	19,947
Inventory	10,754	11,346
Other current assets	4,008	9,814
Total current assets	282,522	350,051
Property, plant and equipment, net	65,553	71,336
Goodwill	76,501	76,501
Other assets	519	754
Total assets	425,095	498,642
Current liabilities:
Accounts payable	7,118	2,363
Accrued compensation	15,733	5,998
Accrued clinical trial expenses	10,946	8,220
Other accrued expenses	6,761	4,156
Interest payable	4,198	4,198
Capital lease obligations, current portion	2,370	4,756
Liability related to refundable upfront payment	12,500	0
Deferred revenue, current portion	14,101	21,428
Other current liabilities	2,578	10,127
Total current liabilities	76,305	61,246
Senior secured notes, net	243,004	241,699
Capital lease obligations, less current portion	2,143	1,073
Liability related to the sale of future royalties, net	108,893	116,029
Deferred revenue, less current portion	57,088	62,426
Other long-term liabilities	5,515	9,740
Total liabilities	492,948	492,213
Commitments and contingencies
Stockholders’ equity (deficit):
Preferred stock, $0.0001 par value; 10,000 shares authorized; no shares designated, issued or outstanding at September 30, 2016 or December 31, 2015	0	0
Common stock, $0.0001 par value; 300,000 shares authorized; 137,796 shares and 135,289 shares issued and outstanding at September 30, 2016 and December 31, 2015, respectively	13	13
Capital in excess of par value	1,912,907	1,876,072
Accumulated other comprehensive loss	(1,962)	(2,170)
Accumulated deficit	(1,978,811)	(1,867,486)
Total stockholders’ equity (deficit)	(67,853)	6,429
Total liabilities and stockholders’ equity (deficit)	$ 425,095	$ 498,642