Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015
Cash flows from operating activities:
Net loss	$ (68,101)	$ (18,837)
Adjustments to reconcile net loss to net cash (used in) provided by operating activities:
Non-cash royalty revenue related to sale of future royalties	(14,650)	(8,702)
Non-cash interest expense on liability related to sale of future royalties	10,027	10,202
Stock-based compensation	12,627	9,737
Depreciation and amortization	7,634	5,833
Other non-cash transactions	(1,260)	(621)
Changes in operating assets and liabilities:
Accounts receivable, net	(7,830)	(73)
Inventory	1,084	2,828
Other assets	4,637	190
Accounts payable	17	(10)
Accrued compensation	6,465	5,075
Accrued clinical trial expenses	5,250	1,238
Other accrued expenses	2,831	1,859
Interest payable	(54)	0
Liability related to refundable upfront payment	12,500	0
Deferred revenue	(7,704)	(4,434)
Other liabilities	(725)	11,772
Net cash (used in) provided by operating activities	(37,252)	16,057
Cash flows from investing activities:
Purchases of investments	(72,806)	(124,468)
Maturities of investments	107,363	111,001
Sales of investments	0	5,215
Purchases of property, plant and equipment	(3,234)	(4,584)
Net cash provided by (used in) investing activities	31,323	(12,836)
Cash flows from financing activities:
Payment of capital lease obligations	(3,517)	(2,484)
Proceeds from shares issued under equity compensation plans	9,643	7,798
Net cash provided by financing activities	6,126	5,314
Effect of exchange rates on cash and cash equivalents	(91)	(25)
Net increase in cash and cash equivalents	106	8,510
Cash and cash equivalents at beginning of period	55,570	12,365
Cash and cash equivalents at end of period	55,676	20,875
Supplemental disclosure of cash flow information:
Cash paid for interest	$ 10,448	$ 8,320