Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015	Jun. 30, 2016	Jun. 30, 2015
Revenue:
Product sales	$ 12,867	$ 10,968	$ 26,966	$ 18,942
Royalty revenue	3,516	745	7,576	870
Non-cash royalty revenue related to sale of future royalties	8,115	4,740	14,650	8,702
License, collaboration and other revenue	8,270	6,208	42,457	102,948
Total revenue	32,768	22,661	91,649	131,462
Operating costs and expenses:
Cost of goods sold	7,708	10,534	16,578	18,978
Research and development	52,350	45,412	101,618	92,423
General and administrative	11,035	10,184	21,262	20,487
Total operating costs and expenses	71,093	66,130	139,458	131,888
Loss from operations	(38,325)	(43,469)	(47,809)	(426)
Non-operating income (expense):
Interest expense	(5,627)	(4,118)	(11,304)	(8,289)
Non-cash interest expense on liability related to sale of future royalties	(4,982)	(5,152)	(10,027)	(10,202)
Interest income and other income (expense), net	458	246	1,333	457
Total non-operating expense, net	(10,151)	(9,024)	(19,998)	(18,034)
Loss before provision for income taxes	(48,476)	(52,493)	(67,807)	(18,460)
Provision for income taxes	127	164	294	377
Net loss	$ (48,603)	$ (52,657)	$ (68,101)	$ (18,837)
Basic and diluted net loss per share	$ (0.36)	$ (0.40)	$ (0.50)	$ (0.14)
Weighted average shares outstanding used in computing net loss per share	136,350	131,643	136,072	131,502