Commitments and Contingencies - Additional Information (Detail) - USD ($)	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Aug. 14, 2015
Loss Contingencies [Line Items]
Royalty expense	$ 2,800,000	$ 3,400,000	$ 4,100,000
Purchase commitments related to contract manufacturing, clinical development and certain other items	5,400,000
Damage claim for unpaid licensing fee				$ 1,500,000
Indemnification Obligation [Member]
Loss Contingencies [Line Items]
Indemnification obligations, liabilities	0	$ 0
Merger and Acquisition Related Claims [Member]
Loss Contingencies [Line Items]
Obligations under Director and Officer Indemnifications per incident	1,500,000
Securities Related Claims [Member]
Loss Contingencies [Line Items]
Obligations under Director and Officer Indemnifications per incident	1,000,000
Non-Securities Related Claims [Member]
Loss Contingencies [Line Items]
Obligations under Director and Officer Indemnifications per incident	$ 500,000