Property, Plant and Equipment - Property, Plant and Equipment (Detail) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	$ 165,592	$ 147,866
Less: accumulated depreciation	(102,712)	(93,807)
Depreciable property, plant and equipment, net	62,880	54,059
Construction-in-progress	8,456	16,309
Property plant and equipment, net	71,336	70,368
Building and Leasehold Improvements [Member]
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	77,665	72,228
Laboratory Equipment [Member]
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	27,309	26,975
Manufacturing Equipment [Member]
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	35,631	25,212
Furniture, Fixtures and Other Equipment [Member]
Property, Plant and Equipment [Line Items]
Depreciable property and equipment at cost	$ 24,987	$ 23,451