Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Revenue:
Product sales	$ 40,155	$ 25,152	$ 44,846
Royalty revenue	2,967	329	1,148
Non-cash royalty revenue related to sale of future royalties	22,058	21,937	22,055
License, collaboration and other revenue	165,604	153,289	80,872
Total revenue	230,784	200,707	148,921
Operating costs and expenses:
Cost of goods sold	34,102	28,533	38,509
Research and development	182,787	147,734	190,010
General and administrative	43,266	40,925	40,532
Total operating costs and expenses	260,155	217,192	269,051
Loss from operations	(29,371)	(16,485)	(120,130)
Non-operating income (expense):
Interest expense	(18,282)	(17,869)	(18,453)
Non-cash interest expense on liability related to sale of future royalties	(20,619)	(20,888)	(22,309)
Loss on extinguishment of debt	(14,079)	0	0
Interest income and other income (expense), net	1,680	814	1,124
Total non-operating expense, net	(51,300)	(37,943)	(39,638)
Loss before provision (benefit) for income taxes	(80,671)	(54,428)	(159,768)
Provision (benefit) for income taxes	506	(512)	2,245
Net loss	$ (81,177)	$ (53,916)	$ (162,013)
Basic and diluted net loss per share	$ (0.61)	$ (0.42)	$ (1.40)
Weighted average shares outstanding used in computing basic and diluted net loss per share	132,458	126,873	115,732