Property, Plant and Equipment (Tables)

12 Months Ended

Dec. 31, 2015

Property Plant And Equipment [Abstract]

Property, Plant and Equipment

Property, plant and equipment consists of the following (in thousands):

	December 31,
	2015			2014
Building and leasehold improvements	$	77,665		$	72,228
Laboratory equipment		27,309			26,975
Manufacturing equipment		35,631			25,212
Furniture, fixtures and other equipment		24,987			23,451
Depreciable property, plant and equipment at cost		165,592			147,866
Less: accumulated depreciation		(102,712	)		(93,807	)
Depreciable property, plant and equipment, net		62,880			54,059
Construction-in-progress		8,456			16,309
Property, plant and equipment, net	$	71,336		$	70,368