Segment Reporting

12 Months Ended

Dec. 31, 2015

Segment Reporting [Abstract]

Segment Reporting

Note 13 — Segment Reporting

We operate in one business segment which focuses on applying our technology platforms to improve the performance of established and novel medicines. We operate in one segment because our business offerings have similar economics and other characteristics, including the nature of products and manufacturing processes, types of customers, distribution methods and regulatory environment. We are comprehensively managed as one business segment by our Chief Executive Officer and his management team.  

Our revenue is derived primarily from clients in the pharmaceutical and biotechnology industries. AstraZeneca and UCB represented 57% and 13% of our revenue, respectively, for the year ended December 31, 2015. Revenue from AstraZeneca, UCB and Roche represented 52%, 16% and 11% of our revenue, respectively, for the year ended December 31, 2014.  Revenue from Roche, UCB, AstraZeneca and Bayer represented 28%, 21%, 17% and 10% of our revenue, respectively, for the year ended December 31, 2013.

Revenue by geographic area is based on the locations of our partners. The following table sets forth revenue by geographic area (in thousands):

	Year Ended December 31,
	2015		2014		2013
United States	$	40,400	$	32,514	$	42,535
Europe		190,384		168,193		106,386
Total revenue	$	230,784	$	200,707	$	148,921

At December 31, 2015, $54.2 million, or approximately 76%, of the net book value of our property, plant and equipment was located in the United States, $11.1 million, or approximately 16% was located at contract manufacturers in Germany and the Netherlands, and $6.0 million, or approximately 8%, was located in India. At December 31, 2014, $53.3 million, or approximately 76%, of the net book value of our property, plant and equipment was located in the United States, $10.4 million, or approximately 14% was located at contract manufacturers in Germany and the Netherlands, and $6.7 million, or approximately 10%, was located in India.