Consolidated Balance Sheets - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Current assets:
Cash and cash equivalents	$ 55,570	$ 12,365
Short-term investments	253,374	225,459
Accounts receivable, net of allowance of nil at December 31, 2015 and 2014	19,947	3,607
Inventory	11,346	12,952
Restricted cash	0	25,000
Other current assets	9,814	8,817
Total current assets	350,051	288,200
Property, plant and equipment, net	71,336	70,368
Goodwill	76,501	76,501
Other assets	4,173	6,552
Total assets	502,061	441,621
Current liabilities:
Accounts payable	2,363	2,703
Accrued compensation	5,998	5,749
Accrued clinical trial expenses	8,220	7,708
Other accrued expenses	4,156	6,418
Interest payable	4,198	6,917
Capital lease obligations, current portion	4,756	4,512
Deferred revenue, current portion	21,428	24,473
Other current liabilities	10,127	5,567
Total current liabilities	61,246	64,047
Senior secured notes, net	242,115	125,000
Capital lease obligations, less current portion	1,073	4,139
Liability related to the sale of future royalties	119,032	120,471
Deferred revenue, less current portion	62,426	76,911
Other long-term liabilities	9,740	14,721
Total liabilities	$ 495,632	$ 405,289
Commitments and contingencies
Stockholders’ equity:
Preferred stock, $0.0001 par value; 10,000 shares authorized; no shares designated, issued or outstanding at December 31, 2015 or 2014	$ 0	$ 0
Common stock, $0.0001 par value; 300,000 shares authorized; 135,289 shares and 131,216 shares issued and outstanding at December 31, 2015 and 2014, respectively	13	13
Capital in excess of par value	1,876,072	1,824,195
Accumulated other comprehensive loss	(2,170)	(1,567)
Accumulated deficit	(1,867,486)	(1,786,309)
Total stockholders’ equity	6,429	36,332
Total liabilities and stockholders’ equity	$ 502,061	$ 441,621