X0306 4 2021-12-16 0 0000906709 NEKTAR THERAPEUTICS NKTR 0001394875 Labrucherie Gil M C/O NEKTAR THERAPEUTICS 455 MISSION BAY BOULEVARD SOUTH SAN FRANCISCO CA 94158 0 1 0 0 SVP, COO & CFO Common Stock 2021-12-16 4 A 0 52950 0.00 A 309182 D Stock Option 13.22 2021-12-16 4 A 0 94000 0.00 A 2029-12-15 Common Stock 94000 94000 D This stock award was acquired pursuant to a grant of restricted stock units ("RSUs"). Each RSU represents a contingent right to receive, upon vesting of the unit, one share of the Issuer's common stock. These RSUs vest over three years from the date of grant in substantially equal quarterly installments based on continued service. This number includes 997 shares held by the reporting person in the Issuer's 401(K) plan and 4,218 shares held by the reporting person in the Issuer's ESPP plan. The acquisition of these shares under both plans is exempt under Rule 16b-3(c). This stock option vests over four years from the date of grant in equal monthly installments based on continued service. Mark A. Wilson, Attorney-in-Fact 2021-12-20