X0306 4 2021-09-08 0 0000906709 NEKTAR THERAPEUTICS NKTR 0001227886 CHESS ROBERT C/O NEKTAR THERAPEUTICS 455 MISSION BAY BOULEVARD SOUTH SAN FRANCISCO CA 94158 1 0 0 0 Common Stock 2021-09-08 4 M 0 8000 13.80 A 282273 D Common Stock 2021-09-08 4 S 0 8000 16.00 D 274273 D Common Stock 2021-09-09 4 M 0 10279 13.80 A 284552 D Common Stock 2021-09-09 4 S 0 10279 16.02 D 274273 D Common Stock 2100 I by daughter Common Stock 2100 I by son Common Stock 2100 I by daughter Common Stock 13.80 2021-09-08 4 M 0 8000 0.00 D 2014-09-30 2021-09-18 Common Stock 8000 10279 D Common Stock 13.80 2021-09-09 4 M 0 10279 0.00 D 2014-09-30 2021-09-18 Common Stock 10279 0 D This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person for certain options expiring on September 18, 2021. This transaction was executed in multiple trades at prices ranging from $15.85 to $16.14. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide full information regarding the number of shares and the prices at which the transactions were effected upon request to the SEC staff, the issuer, or a security holder of the issuer. This transaction was executed in multiple trades at prices ranging from $15.76 to $16.26. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide full information regarding the number of shares and the prices at which the transactions were effected upon request to the SEC staff, the issuer, or a security holder of the issuer. The reporting person disclaims beneficial ownership of these shares, and this report shall not be deemed an admission that the reporting person is the beneficial owner of these shares for purposes of Section 16 or for any other purpose. Mark A. Wilson, Attorney-in-Fact 2021-09-10