Condensed Consolidated Statements of Operations (Unaudited) (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended		6 Months Ended
	Jun. 30, 2012	Jun. 30, 2011	Jun. 30, 2012	Jun. 30, 2011
Revenue:
Product sales and royalties	$ 13,453	$ 11,008	$ 23,575	$ 15,801
License, collaboration and other	10,231	6,323	18,058	12,829
Total revenue	23,684	17,331	41,633	28,630
Operating costs and expenses:
Cost of goods sold	7,203	8,140	15,910	11,403
Research and development	33,201	32,270	68,286	62,446
General and administrative	10,268	11,185	20,682	22,912
Impairment of long-lived assets			1,675
Total operating costs and expenses	50,672	51,595	106,553	96,761
Loss from operations	(26,988)	(34,264)	(64,920)	(68,131)
Non-operating income (expense):
Interest income	630	529	1,262	961
Interest expense	(7,931)	(2,570)	(12,264)	(5,155)
Other income (expense), net	97	(16)	757	118
Total non-operating expense	(7,204)	(2,057)	(10,245)	(4,076)
Loss before provision for income taxes	(34,192)	(36,321)	(75,165)	(72,207)
Provision for income taxes	93	60	217	208
Net loss	$ (34,285)	$ (36,381)	$ (75,382)	$ (72,415)
Basic and diluted net loss per share	$ (0.30)	$ (0.32)	$ (0.66)	$ (0.65)
Weighted average shares outstanding used in computing basic and diluted net loss per share	114,649	114,153	114,590	111,430