<?xml version="1.0" encoding="US-ASCII"?>
<!-- Generated by Broadridge Transform (tm) - http://www.broadridge.com -->
<!-- Created: Fri Apr 24 20:15:29 UTC 2026 -->
<xs:schema elementFormDefault="qualified" targetNamespace="http://nektar.com/20260604" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:nktr="http://nektar.com/20260604" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:us-types="http://xbrl.us/us-types/2009-01-31" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:dtr="http://www.xbrl.org/dtr/type/2024-01-31" xmlns:xbrli="http://www.xbrl.org/2003/instance">
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/ecd/2025" schemaLocation="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei/2025" schemaLocation="https://xbrl.sec.gov/dei/2025/dei-2025.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2024-01-31" schemaLocation="https://www.xbrl.org/dtr/type/2024-01-31/types.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/ecd-sub/2025" schemaLocation="https://xbrl.sec.gov/ecd/2025/ecd-sub-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei-sub/2025" schemaLocation="https://xbrl.sec.gov/dei/2025/dei-sub-2025.xsd"/>
<!-- [WMV7][P42i+TAJh/ex9plYtalfaldSJ/ioD6qswl61tqgUtGvkJ/pv1Lli+nFzPcY1QecPP9lhWSqOixa2Ktz3o9dFAAw5lUYATOeYZHNn+yqzT1/XalE9aHDerNEhQa8SrOk07E3BsKca8sTMHv6w/pzVH4GblFdxHv9QVaR2/xtMEWMt7YNEVqc5Ve58oqPH52TCDahTkJ9icUHCidL4dbgdLPSGXW/KDosuVyJ6ZVQL3Q+zlB0W/s5KmcWia3dZ+SbMGiXgEky5FiL017GN8RWEvFAQMHY2nWY30+t8rbG60wSE7A8d/7ZLxCsxTw9a4pScSIAYJk4mbt8RCtQLtGTH9p3kizfCNtoiiHVxsZsxpd9EMaUAtaoc3g==] CSR-->
  <xs:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
</xs:schema>