CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2025	Jun. 30, 2024
Cash flows from operating activities:
Net loss	$ (92,475)	$ (89,165)
Adjustments to reconcile net loss to net cash used in operating activities:
Non-cash royalty revenue related to the sales of future royalties	(21,635)	(32,298)
Non-cash interest expense on liabilities related to the sales of future royalties	10,368	11,939	[1]
Loss from equity method investment	6,847	0	[1]
Stock-based compensation	7,384	11,418
Depreciation and amortization expense	640	3,066
Impairment of right-of-use assets and property and equipment	0	8,329
Provision for net realizable value of inventory	0	2,567
Amortization of premiums (discounts), net	(2,193)	(5,647)
Changes in operating assets and liabilities:
Accounts receivable	0	9
Inventory	0	(931)
Operating leases, net	(5,580)	(4,196)
Other assets	(4,973)	1,817
Accounts payable	2,886	(3,266)
Accrued expenses	3,940	10,768
Net cash used in operating activities	(94,791)	(85,590)
Cash flows from investing activities:
Purchases of investments	(43,852)	(173,504)
Maturities of investments	137,892	210,087
Purchases of property and equipment	(39)	(343)
Payment of transaction costs and working capital adjustment from the sale of the Huntsville manufacturing facility	(697)	0
Net cash provided by investing activities	93,304	36,240
Cash flows from financing activities:
Proceeds from shares issued under equity compensation plans	218	22
Proceeds from issuance of pre-funded warrant	0	30,000
Proceeds from sale of future royalties	0	15,000
Repurchase of common stock from Bristol-Myers Squibb	0	(3,000)
Net cash provided by financing activities	218	42,022
Effect of foreign exchange rates on cash and cash equivalents	5	(9)
Net decrease in cash and cash equivalents	(1,264)	(7,337)
Cash and cash equivalents at beginning of period	44,252	35,277
Cash and cash equivalents at end of period	$ 42,988	$ 27,940

[1] All share and per share amounts have been retrospectively adjusted to reflect a one-for-fifteen reverse stock split (see Note 6).