CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2024	Sep. 30, 2023
Cash flows from operating activities:
Net loss	$ (126,222)	$ (233,977)
Adjustments to reconcile net loss to net cash used in operating activities:
Non-cash royalty revenue related to the sales of future royalties	(48,029)	(50,860)
Non-cash interest expense on liabilities related to the sales of future royalties	17,959	18,467
Stock-based compensation	16,809	26,134
Depreciation and amortization	4,059	6,163
Deferred income tax expense	(12)	(1,854)
Impairment of right-of-use assets and property, plant and equipment	8,329	36,628
Impairment of goodwill	0	76,501
Provision for net realizable value of inventory	20	4,444
Amortization of premiums (discounts), net and other non-cash transactions	(7,711)	(12,137)
Changes in operating assets and liabilities:
Accounts receivable	(841)	3,777
Inventory	(808)	(372)
Operating leases, net	(7,620)	(6,078)
Other assets	(1,761)	4,450
Accounts payable	(1,023)	(9,328)
Accrued expenses	17,329	(7,517)
Net cash used in operating activities	(129,522)	(145,559)
Cash flows from investing activities:
Purchases of investments	(191,882)	(372,821)
Maturities of investments	275,247	494,385
Purchases of property, plant and equipment	(1,009)	(628)
Sale of property, plant and equipment		1,245
Net cash provided by investing activities	82,356	122,181
Cash flows from financing activities:
Proceeds from shares issued under equity compensation plans	35	18
Proceeds from issuance of pre-funded warrant	30,000	0
Proceeds from sale of future royalties	15,000	0
Repurchase of common stock from Bristol-Myers Squibb	(3,000)	0
Net cash provided by financing activities	42,035	18
Effect of foreign exchange rates on cash and cash equivalents	(37)	54
Net increase (decrease) in cash and cash equivalents	(5,168)	(23,306)
Cash and cash equivalents at beginning of period	35,277	88,227
Cash and cash equivalents at end of period	$ 30,109	64,921
Supplemental disclosure of cash flow information:
Cash paid for income taxes		$ 2,656