Restructuring, Impairment and Costs of Terminated Program - Sublease Information (Details) - USD ($)	3 Months Ended			9 Months Ended
	Sep. 30, 2024	Mar. 31, 2024	Sep. 30, 2023	Sep. 30, 2024	Sep. 30, 2023	Jun. 30, 2023	Dec. 31, 2022
Restructuring Cost and Reserve [Line Items]
Book value in excess of fair value					$ 36,962,000
Less: Amounts recorded as amortization for Third St. facility and Mission Bay facility					(1,633,000)
Impairment expense for facilities	$ 0	$ 0	$ 10,567,000		35,329,000
(Gain) on sale or disposal of property, plant, and equipment			(394,000)
Impairment of other property, plant and equipment					1,299,000
Total impairment of right-of-use assets and property, plant and equipment	0		10,173,000	$ 8,329,000	36,628,000
Reported Value Measurement
Restructuring Cost and Reserve [Line Items]
Property, plant and equipment and operating lease right-of-use assets	14,403,000			14,403,000		$ 21,880,000	$ 53,498,000
Property, Plant and Equipment
Restructuring Cost and Reserve [Line Items]
Book value in excess of fair value					5,034,000
Less: Amounts recorded as amortization for Third St. facility and Mission Bay facility					(263,000)
Impairment expense for facilities			1,400,000		4,771,000
(Gain) on sale or disposal of property, plant, and equipment			(394,000)
Impairment of other property, plant and equipment					1,299,000
Total impairment of right-of-use assets and property, plant and equipment			1,006,000	1,042,000	6,070,000
Property, Plant and Equipment | Reported Value Measurement
Restructuring Cost and Reserve [Line Items]
Property, plant and equipment and operating lease right-of-use assets	1,897,000			1,897,000		3,050,000	7,206,000
Operating Lease Right-of-Use Assets
Restructuring Cost and Reserve [Line Items]
Book value in excess of fair value					31,928,000
Less: Amounts recorded as amortization for Third St. facility and Mission Bay facility					(1,370,000)
Impairment expense for facilities			9,167,000		30,558,000
(Gain) on sale or disposal of property, plant, and equipment			0
Total impairment of right-of-use assets and property, plant and equipment			$ 9,167,000	7,287,000	$ 30,558,000
Operating Lease Right-of-Use Assets | Reported Value Measurement
Restructuring Cost and Reserve [Line Items]
Property, plant and equipment and operating lease right-of-use assets	12,506,000			12,506,000		18,830,000	46,292,000
Fair Value, Level 3 | Estimate of Fair Value Measurement
Restructuring Cost and Reserve [Line Items]
Property, plant and equipment and operating lease right-of-use assets	(6,074,000)			(6,074,000)		(11,313,000)	(16,536,000)
Fair Value, Level 3 | Property, Plant and Equipment | Estimate of Fair Value Measurement
Restructuring Cost and Reserve [Line Items]
Property, plant and equipment and operating lease right-of-use assets	(855,000)			(855,000)		(1,650,000)	(2,172,000)
Fair Value, Level 3 | Operating Lease Right-of-Use Assets | Estimate of Fair Value Measurement
Restructuring Cost and Reserve [Line Items]
Property, plant and equipment and operating lease right-of-use assets	$ (5,219,000)			$ (5,219,000)		$ (9,663,000)	$ (14,364,000)