CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2024	Sep. 30, 2023	Sep. 30, 2024	Sep. 30, 2023
Revenue:
Total revenue	$ 24,124	$ 24,144	$ 69,252	$ 66,237
Operating costs and expenses:
Cost of goods sold	4,435	12,431	22,709	26,485
Research and development	35,031	24,070	92,163	84,220
General and administrative	18,957	21,147	59,616	60,097
Restructuring, impairment, and costs of terminated program	46	11,360	14,310	49,107
Impairment of goodwill	0	0	0	76,501
Total operating costs and expenses	58,469	69,008	188,798	296,410
Loss from operations	(34,345)	(44,864)	(119,546)	(230,173)
Non-operating income (expense):
Non-cash interest expense on liabilities related to the sales of future royalties	(6,020)	(5,910)	(17,959)	(18,467)
Interest income	3,437	5,211	11,558	14,392
Other income (expense), net	(120)	(335)	(255)	100
Total non-operating income (expense), net	(2,703)	(1,034)	(6,656)	(3,975)
Loss before provision for income taxes	(37,048)	(45,898)	(126,202)	(234,148)
Provision (benefit) for income taxes	9	(61)	20	(171)
Net loss	$ (37,057)	$ (45,837)	$ (126,222)	$ (233,977)
Basic net loss per share (in dollars per share)	$ (0.18)	$ (0.24)	$ (0.62)	$ (1.23)
Diluted net loss per share (in dollars per share)	$ (0.18)	$ (0.24)	$ (0.62)	$ (1.23)
Weighted average shares outstanding used in computing basic net loss per share (in shares)	209,249	190,406	204,292	189,651
Weighted average shares outstanding used in computing diluted net loss per share (in shares)	209,249	190,406	204,292	189,651
Product sales
Revenue:
Total revenue	$ 8,015	$ 5,822	$ 20,689	$ 15,198
Non-cash royalty revenue related to the sales of future royalties
Revenue:
Total revenue	15,731	18,167	48,029	50,860
License, collaboration and other revenue
Revenue:
Total revenue	$ 378	$ 155	$ 534	$ 179