CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
Revenue:
Total revenue	$ 23,489	$ 20,499	$ 45,128	$ 42,093
Operating costs and expenses:
Cost of goods sold	9,740	6,994	18,274	14,054
Research and development	29,724	29,681	57,132	60,150
General and administrative	20,510	17,869	40,659	38,950
Restructuring, impairment and costs of terminated program	13,289	16,554	14,264	37,747
Impairment of goodwill	0	0	0	76,501
Total operating costs and expenses	73,263	71,098	130,329	227,402
Loss from operations	(49,774)	(50,599)	(85,201)	(185,309)
Non-operating income (expense):
Non-cash interest expense on liabilities related to the sales of future royalties	(6,408)	(6,152)	(11,939)	(12,557)
Interest income	3,901	4,846	8,121	9,181
Other income (expense), net	(36)	736	(135)	435
Total non-operating income (expense), net	(2,543)	(570)	(3,953)	(2,941)
Loss before provision for income taxes	(52,317)	(51,169)	(89,154)	(188,250)
Provision (benefit) for income taxes	46	(47)	11	(110)
Net loss	$ (52,363)	$ (51,122)	$ (89,165)	$ (188,140)
Basic net loss per share (in dollars per share)	$ (0.25)	$ (0.27)	$ (0.44)	$ (0.99)
Diluted net loss per share (in dollars per share)	$ (0.25)	$ (0.27)	$ (0.44)	$ (0.99)
Weighted average shares outstanding used in computing basic net loss per share (in shares)	208,828	189,656	201,787	189,268
Weighted average shares outstanding used in computing diluted net loss per share (in shares)	208,828	189,656	201,787	189,268
Product sales
Revenue:
Total revenue	$ 6,640	$ 4,658	$ 12,674	$ 9,376
Non-cash royalty revenue related to the sales of future royalties
Revenue:
Total revenue	16,790	15,832	32,298	32,693
License, collaboration and other revenue
Revenue:
Total revenue	$ 59	$ 9	$ 156	$ 24