CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended	12 Months Ended			142 Months Ended
	Mar. 31, 2023	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2023
Cash flows from operating activities:
Net loss		$ (276,056)	$ (368,198)	$ (523,837)
Adjustments to reconcile net loss to net cash used in operating activities:
Non-cash royalty revenue related to the sales of future royalties		(68,921)	(69,794)	(77,746)	$ (472,166)
Non-cash interest expense on liabilities related to sales of future royalties		25,334	28,911	47,313	298,518
Loss on revaluation of liability related to the sale of future royalties		0	0	24,410
Change in fair value of development derivative liability		0	(33,427)	8,023
Non-cash research and development expense		0	4,951	16,703
Stock-based compensation		33,388	57,320	94,674
Depreciation and amortization		7,815	13,030	14,146
Deferred income tax expense		(140)	2,708	(102)
Impairment of right-of-use assets and property, plant and equipment		35,328	65,761	0
Impairment of goodwill	$ 76,500	76,501	0	0
(Gain) loss on sale or disposal of property, plant and equipment, net		1,300	(3,326)	0
Provision for inventory obsolescence		2,402	0	0
Foreign currency translation adjustment		5,099	0	0
Amortization of premiums (discounts), net and other non-cash transactions		(14,856)	(2,435)	6,730
Changes in operating assets and liabilities:
Accounts receivable		4,776	16,511	12,397
Inventory		699	(3,401)	(509)
Operating leases, net		(8,850)	(2,680)	2,340
Other assets		3,583	6,906	(2,586)
Accounts payable		(2,884)	3,103	(11,690)
Accrued expenses		(17,124)	(19,947)	(22,926)
Net cash used in operating activities		(192,606)	(304,007)	(412,660)
Cash flows from investing activities:
Purchases of investments		(511,699)	(467,914)	(960,689)
Maturities of investments		650,883	826,229	1,166,951
Sales of investments		0	0	11,504
Purchases of property, plant and equipment		(865)	(5,676)	(14,989)
Sales of property, plant and equipment		1,245	13,196	0
Net cash provided by investing activities		139,564	365,835	202,777
Cash flows from financing activities:
Cash receipts from development derivative liability		0	750	3,000
Proceeds from shares issued under equity compensation plans		30	758	33,238
Net cash provided by financing activities		30	1,508	36,238
Effect of foreign exchange rates on cash and cash equivalents		62	(327)	(92)
Net increase (decrease) in cash and cash equivalents		(52,950)	63,009	(173,737)
Cash and cash equivalents at beginning of year	$ 88,227	88,227	25,218	198,955
Cash and cash equivalents at end of year		35,277	88,227	25,218	$ 35,277
Supplemental disclosure of cash flow information:
Operating lease right-of-use assets recognized in exchange for lease liabilities		0	0	1,057
Cash paid for income taxes		$ 2,656	$ 272	$ 325