CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
Cash flows from operating activities:
Net loss	$ (233,977)	$ (308,510)
Adjustments to reconcile net loss to net cash used in operating activities:
Non-cash royalty revenue related to the sales of future royalties	(50,860)	(52,167)
Non-cash interest expense on liabilities related to the sales of future royalties	18,467	21,710
Change in fair value of development derivative liability	0	(33,427)
Non-cash research and development expense	0	4,951
Stock-based compensation	26,134	44,582
Depreciation and amortization	6,163	9,848
Deferred income tax expense	(1,854)	0
Impairment of right-of-use assets and property, plant and equipment	36,628	58,521
Impairment of goodwill	76,501	0
Provision for inventory obsolescence	4,444
Amortization of premiums (discounts), net and other non-cash transactions	(12,137)	(372)
Changes in operating assets and liabilities:
Accounts receivable	3,777	10,960
Inventory	(372)	(3,256)
Operating leases, net	(6,078)	(1,423)
Other assets	4,450	4,861
Accounts payable	(9,328)	(4,184)
Accrued expenses	(7,517)	1,602
Net cash used in operating activities	(145,559)	(246,304)
Cash flows from investing activities:
Purchases of investments	(372,821)	(295,439)
Maturities of investments	494,385	626,424
Purchases of property, plant and equipment	(628)	(5,164)
Sale of property, plant and equipment	1,245	0
Net cash provided by investing activities	122,181	325,821
Cash flows from financing activities:
Proceeds from shares issued under equity compensation plans	18	655
Cash receipts from development derivative liability	0	750
Net cash provided by financing activities	18	1,405
Effect of foreign exchange rates on cash and cash equivalents	54	(382)
Net increase (decrease) in cash and cash equivalents	(23,306)	80,540
Cash and cash equivalents at beginning of period	88,227	25,218
Cash and cash equivalents at end of period	64,921	105,758
Supplemental disclosures of cash flow information:
Cash paid for income taxes	$ 2,656	$ 0