Condensed Consolidated Statements of Operations (Unaudited) (USD $) In Thousands, except Per Share data	3 Months Ended		6 Months Ended
	Jun. 30, 2011	Jun. 30, 2010	Jun. 30, 2011	Jun. 30, 2010
Revenue:
Product sales and royalties	$ 11,008	$ 11,154	$ 15,801	$ 14,738
License, collaboration and other	6,323	31,409	12,829	61,062
Total revenue	17,331	42,563	28,630	75,800
Operating costs and expenses:
Cost of goods sold	8,140	4,889	11,403	9,185
Research and development	32,270	25,600	62,446	48,886
General and administrative	11,185	10,207	22,912	19,220
Total operating costs and expenses	51,595	40,696	96,761	77,291
Income (loss) from operations	(34,264)	1,867	(68,131)	(1,491)
Non-operating income (expense):
Interest income	529	393	961	856
Interest expense	(2,570)	(2,909)	(5,155)	(5,860)
Other income (expense), net	(16)	163	118	187
Total non-operating expense	(2,057)	(2,353)	(4,076)	(4,817)
Loss before provision for income taxes	(36,321)	(486)	(72,207)	(6,308)
Provision for income taxes	60	31	208	339
Net loss	$ (36,381)	$ (517)	$ (72,415)	$ (6,647)
Basic and diluted net loss per share	$ (0.32)	$ (0.01)	$ (0.65)	$ (0.07)
Weighted average shares outstanding used in computing basic and diluted net loss per share	114,153	94,065	111,430	93,849